If you're preparing for an interview, it's always a good idea to get a sense of what the interviewer (and their editor) wants to cover, even if you know you're not going to get a full list of questions.
And to be honest, there's usually a big question that's the reason why you're there in the first place - either your reason or the reason that the media outlet's contacted you.
Krishnan Guru-Murthy of Channel 4 News has written a piece on his blog about how awkward it can be, from the reporter's point of view, to ask some of those big questions.